Fortunately for the Blues, they have been in solid form recently. Away wins over Burnley and Swansea City have created momentum for a team set to return to the FA Cup final for the second season in a row.
Wenger is bowing out at Arsenal, while Southampton are determined not to suffer relegation without a fight. Saints may see an Everton side comfortable in eighth as ripe to surrender precious points on Saturday.
Konstantinos Mavropanos Premier League debut by numbers vs. Man Utd: 92% pass accuracy 49 touches 37 passes 4 clearances 3 interceptions 2 blocked shots 1 tackle won 0 fouls committed Solid start.
It will be fitting for his final batch of young prospects to make the difference against a Burnley side that has given everything to reach seventh.
Everton vs. Southampton: 5:30 p.m. BST / 12:30 p.m. ET, BT Sport 1/NBC (Draw)
Wengers sendoff will be an occasion, but the matchdays most significant game in the top half of the table is Liverpools visit to Chelsea.
Fabregas will dovetaill with strikers Alvaro Morata and Olivier Giroud. Their aerial threat could undermine a Liverpool back line that is still vulnerable at times.
Wengers side can cement sixth place with another home win. Three points should belong to Arsenal, even if the Gunners are still down after being eliminated from the UEFA Europa League by Atletico Madrid at the semi-final stage on Thursday.
If the Reds have one eye on the UEFA Champions League final, Chelsea will capitalise.
Sunday will also see Arsene Wenger take charge of his final home game as Arsenal manager when the Gunners welcome Burnley to north London.
Chelsea host Liverpool in the standout fixture of the penultimate weekend of the 2017/18 Premier League season, with crucial points in the battle to qualify for next seasons UEFA Champions League on the line.
Dusan Tadic netted a brace against the Cherries, and he has the craft and vision to unlock an inconsistent Everton back line. The Toffees have kept clean sheets in their past two matches, both wins, against Huddersfield Town and Newcastle United.
Leicester City vs. West Ham United: 3 p.m. BST / 10 a.m. ET, NBC Sports Gold (Draw)
The Reds arrive at Stamford Bridge six points ahead of their rivals in the race for a top-four finish. However, Chelsea have a game in hand, an advantage they will only make count by first beating Liverpool on Sunday.
Watford vs. Newcastle United: 3 p.m. BST / 10 a.m. ET, NBC Sports Gold (Draw)
Wengers tenure has been defined by his willingness to give youth a chance.
The Frenchman will step down at the end of the season after nearly 22 years as boss. Arsenal are planning to mark the occasion with a post-match presentation and withmany members of Arsenals 100 Clubplayers to have made more than 100 appearances, perJames Olleyof theLondon Evening Standard.
Southampton gave themselves a fighting chance of survival by beating Bournemouth 2-1 in their most recent game. Saints have the players to bank at least a precious point when they travel to Merseyside to meet Everton on Saturday evening.
Yet Everton conceded 54 goals in their other 34 games. If Tadic can thread the passes for strikers Shane Long and Charlie Austin, Saints will get on the scoresheet at Goodison Park.
Southampton are just a point off safety, so they need at least a draw to claw out of the relegation zone ahead of their final two games of the season.
Burnleys trip to Arsenal on Sunday is unlikely to affect the table, but its still significant given it is Wengers last home game in charge of the Gunners.
Manchester City vs. Huddersfield Town: 1:30 p.m. BST / 8:30 a.m. ET, Sky Sports PL/NBCSN (City)
With Arsenal unable to secure a top-four finish, Wenger has the chance to continue blooding younger players. He did something similar for the recent 2-1 defeat to Manchester United at Old Trafford and saw positive performances from two precocious talents.
Arsenal vs. Burnley: 4:30 p.m. BST / 11:30 a.m. ET, CNBC (Arsenal)
Chelseas revival has been built on a mix of brawn and skill in the final third. The latter quality is embodied by midfield playmakerCesc Fabregas, who scored the winner against the Swans last time out.
In the process, Fabregas joined a select group of Spanish players in the annals of Premier League history, per BBCMatch of the Day:
Even so, its unlikely Southampton will keep a clean sheet against a steadily improving Toffees forward line defined by the complementary talents of powerhouse forward Cenk Tosun and pacey wingerTheo Walcott.
Chelsea vs. Liverpool: 4:30 p.m. BST / 11:30 a.m. ET, Sky Sports PL/NBCSN (Chelsea)